Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867848 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2HSD17B10P4HTMMEN1KMT2A | |
| SCHEMBL7871660 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2OPRM1OPRD1OPRK1P4HTM | |
| SCHEMBL7862681 | 0.91 | HSD17B10 (0.43) | SMN1; SMN2HSD17B10P4HTMMEN1KMT2A | |
| SCHEMBL7869413 | 0.90 | SMPD1 (0.45) | SMN1; SMN2HSD17B10KMT2AGABRA5 | |
| SCHEMBL7870447 | 0.90 | HSD17B10 (0.41) | SMN1; SMN2HSD17B10P4HTMMEN1KMT2A | |
| SCHEMBL7871681 | 0.89 | EGFR (0.46) | OPRM1OPRD1OPRK1P4HTMGABRA5 | |
| SCHEMBL7869480 | 0.89 | HSD17B10 (0.42) | SMN1; SMN2HSD17B10P4HTMMEN1KMT2A | |
| SCHEMBL7862782 | 0.88 | RAB9A (0.49) | SMN1; SMN2HSD17B10P4HTMMEN1KMT2A | |
| SCHEMBL7871628 | 0.88 | HTT (0.53) | HSD17B10P4HTMLMNAHTTHDAC2 | |
| SCHEMBL7870551 | 0.87 | RAB9A (0.49) | SMN1; SMN2HSD17B10P4HTMBCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |