Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867848 | 0.97 | SMN1; SMN2 (0.45) | SMPD1HSD17B10SMN1; SMN2KMT2AFBP1 | |
| SCHEMBL7862883 | 0.92 | KMT2A (0.41) | SMPD1SMN1; SMN2CA2NAAAKMT2A | |
| SCHEMBL7869480 | 0.91 | HSD17B10 (0.42) | SMPD1HSD17B10SMN1; SMN2KMT2AGABRA5 | |
| SCHEMBL7874547 | 0.90 | SMN1; SMN2 (0.43) | HSD17B10SMN1; SMN2KMT2AGABRA5 | |
| SCHEMBL7867792 | 0.90 | CA2 (0.49) | SMPD1CA2NAAAGABRA5 | |
| SCHEMBL7874558 | 0.89 | HDAC2 (0.44) | SMN1; SMN2 | |
| SCHEMBL7862723 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AFBP1GABRA5 | |
| SCHEMBL7862681 | 0.89 | HSD17B10 (0.43) | SMPD1HSD17B10SMN1; SMN2KMT2AGABRA5 | |
| SCHEMBL9018042 | 0.89 | SMN1; SMN2 (0.43) | SMPD1SMN1; SMN2CA2NAAAKMT2A | |
| SCHEMBL7862888 | 0.88 | HDAC2 (0.45) | HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |