Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862888 | 0.97 | HDAC2 (0.45) | HDAC2HDAC8HDAC6ALDH1A1RAB9A | |
| SCHEMBL7862782 | 0.94 | RAB9A (0.49) | HDAC2HDAC8HDAC6ALDH1A1RAB9A | |
| SCHEMBL7862856 | 0.91 | HSP90AA1 (0.46) | ALDH1A1RAB9ASMN1; SMN2NPC1CYP2D6 | |
| SCHEMBL7871628 | 0.91 | HTT (0.53) | HDAC2HDAC8HDAC6ALDH1A1RAB9A | |
| SCHEMBL7869411 | 0.90 | RAB9A (0.48) | HDAC2HDAC8HDAC6ALDH1A1RAB9A | |
| SCHEMBL7871636 | 0.89 | RAB9A (0.46) | HDAC2HDAC8HDAC6ALDH1A1RAB9A | |
| SCHEMBL7869413 | 0.89 | SMPD1 (0.45) | SMN1; SMN2 | |
| SCHEMBL7867848 | 0.89 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2HPGDP4HTMKDM4E | |
| SCHEMBL7870451 | 0.89 | NPC1 (0.46) | RAB9ASMN1; SMN2NPC1EPHX2P4HTM | |
| SCHEMBL8869077 | 0.89 | P4HTM (0.51) | HDAC2HDAC8HDAC6ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |