Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056911 | 0.93 | PDE5A (0.46) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL7868121 | 0.80 | MAPK1 (0.50) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5057159 | 0.79 | MAPK1 (0.39) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL7868065 | 0.77 | MAPK1 (0.48) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL7879205 | 0.75 | EPHX2 (0.38) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL19248928 | 0.72 | SMN1; SMN2 (0.71) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL24011624 | 0.71 | SMN1; SMN2 (0.70) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL8516755 | 0.71 | SMN1; SMN2 (0.90) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL28362881 | 0.70 | SMN1; SMN2 (0.68) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL22170879 | 0.69 | SMN1; SMN2 (0.70) | HDAC3HDAC1HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |