Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868065 | 0.97 | MAPK1 (0.48) | MAPK1TGM2HTTHDAC6FOLH1 | |
| SCHEMBL5057159 | 0.88 | MAPK1 (0.39) | MAPK1TGM2HDAC6HDAC3HDAC4 | |
| SCHEMBL7873367 | 0.82 | TGM2 (0.49) | MAPK1TGM2HTTFOLH1ANPEP | |
| SCHEMBL7874778 | 0.80 | HDAC3 (0.48) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7873416 | 0.76 | ANPEP (0.49) | TGM2HTTANPEPKEAP1NFE2L2 | |
| SCHEMBL7976783 | 0.74 | TGM2 (0.65) | TGM2HTTFOLH1ANPEPKEAP1 | |
| SCHEMBL28085520 | 0.73 | TGM2 (0.67) | TGM2HTTFOLH1KEAP1NFE2L2 | |
| SCHEMBL7879205 | 0.73 | EPHX2 (0.38) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6056911 | 0.72 | PDE5A (0.46) | HTTHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL10422737 | 0.72 | HTT (0.73) | TGM2HTTFOLH1ANPEPKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |