Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621352 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1HPGDACHEHSD17B10 | |
| SCHEMBL5847311 | 0.81 | MAPT (0.47) | KDM4EACHEMAPTCA1CA2 | |
| SCHEMBL27896612 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDACHEMAPT | |
| SCHEMBL8804980 | 0.78 | NPC1 (0.44) | KDM4EALDH1A1HPGDACHEHSD17B10 | |
| SCHEMBL11083951 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDACHEHSD17B10 | |
| SCHEMBL28816282 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1HPGDACHECA1 | |
| SCHEMBL27996928 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1HPGDACHECA1 | |
| SCHEMBL11957272 | 0.72 | KDM4E (0.36) | KDM4EALDH1A1HPGD | |
| SCHEMBL610655 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1HPGDACHECA1 | |
| SCHEMBL7875644 | 0.71 | NPC1 (0.37) | KDM4EALDH1A1HPGDCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196889-A1 | CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2012-08-02 | — | — | US | disclosed |
| WO-2010097087-A1 | CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196889-A1 | CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF | COMT, ADRB3, ADRB1 | KDM4E 2232/4885ALDH1A1 287/4885HPGD 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.