Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30099022 | 0.79 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2HPGDTDP1 | |
| SCHEMBL7874781 | 0.78 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5699500 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8076825 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2238350 | 0.76 | GAA (0.60) | NPC1RAB9ASMN1; SMN2HPGDTDP1 | |
| SCHEMBL2238357 | 0.76 | GAA (0.60) | NPC1RAB9ASMN1; SMN2HPGDTDP1 | |
| SCHEMBL7879190 | 0.76 | PKM (0.54) | RAB9ASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL9491894 | 0.74 | GAA (0.73) | NPC1RAB9ASMN1; SMN2HPGDTDP1 | |
| SCHEMBL11756934 | 0.74 | GAA (0.73) | NPC1RAB9ASMN1; SMN2HPGDTDP1 | |
| SCHEMBL7382201 | 0.74 | ANPEP (0.71) | SMN1; SMN2L3MBTL1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |