Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.33 |
| ▸ | CDK2 | P24941 | 7/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.33 |
| ▸ | LCK | P06239 | 9/20 | 0.32 |
| ▸ | KDR | P35968 | 8/20 | 0.32 |
| ▸ | SRC | P12931 | 8/20 | 0.32 |
| ▸ | HCK | P08631 | 6/20 | 0.32 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | KIT | P10721 | 3/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | LYN | P07948 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | FGR | P09769 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235358 | 0.95 | MTOR (0.32) | ROCK2CYP3A4CHEK1CCNA2CDK2 | |
| SCHEMBL10240296 | 0.90 | CHEK1 (0.43) | ROCK2CYP3A4CHEK1CCNA2CDK2 | |
| SCHEMBL10237007 | 0.87 | LCK (0.38) | CHEK1CCNA2CDK2CCNA1LCK | |
| SCHEMBL7879300 | 0.86 | PIK3CA (0.41) | ROCK2CYP3A4FGFR2 | |
| SCHEMBL7886240 | 0.86 | KDR (0.34) | CHEK1CCNA2CDK2CCNA1LCK | |
| SCHEMBL10238351 | 0.85 | LCK (0.38) | CYP3A4CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7881735 | 0.85 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1LCK | |
| SCHEMBL10235094 | 0.85 | PIK3CA (0.36) | ROCK2CYP3A4CHEK1CCNA2CDK2 | |
| SCHEMBL10238312 | 0.85 | TYRO3 (0.35) | ROCK2CYP3A4CHEK1CCNA2CDK2 | |
| SCHEMBL7875015 | 0.84 | MET (0.33) | CHEK1CCNA2CDK2CCNA1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | ROCK2 3351/4885CYP3A4 3581/4885CHEK1 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.