Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235358 | 0.89 | MTOR (0.32) | MTORPIK3CALCKSRCKDR | |
| SCHEMBL7879269 | 0.89 | LCK (0.32) | MTORPIK3CALCKSRCKDR | |
| SCHEMBL7886688 | 0.84 | PIK3CA (0.43) | MTORPIK3CA | |
| SCHEMBL7875019 | 0.84 | ROCK2 (0.35) | LCKSRCKDRJAK2CSF1R | |
| SCHEMBL7886240 | 0.83 | KDR (0.34) | LCKSRCKDRJAK2CSF1R | |
| SCHEMBL10237007 | 0.83 | LCK (0.38) | LCKSRCKDRRETCHEK1 | |
| SCHEMBL10237951 | 0.83 | LCK (0.39) | METMTORPIK3CALCKSRC | |
| SCHEMBL7881735 | 0.82 | CHEK1 (0.34) | LCKSRCKDRJAK2CSF1R | |
| SCHEMBL10234699 | 0.81 | MTOR (0.42) | METMTORKDRRETKIF5B | |
| SCHEMBL10234708 | 0.81 | CHEK1 (0.44) | METKDRCHEK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |