SCHEMBL7875685

SCHEMBL7875685

COc1cccc(-c2cc(C)ccc2OC)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.55
CYP1A1 P04798 2/20 0.54
CYP1A2 P05177 2/20 0.54
CYP2E1 P05181 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C8 P10632 2/20 0.54
CYP2D6 P10635 2/20 0.54
CYP2A6 P11509 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP4B1 P13584 2/20 0.54
CYP2B6 P20813 2/20 0.54
CYP3A5 P20815 2/20 0.54
CYP2A7 P20853 2/20 0.54
CYP3A7 P24462 2/20 0.54
CYP2F1 P24903 2/20 0.54
CYP2C18 P33260 2/20 0.54
CYP2C19 P33261 2/20 0.54
CYP2J2 P51589 2/20 0.54
CYP4F2 P78329 2/20 0.54
CYP4F8 P98187 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30728871 1.00 ACHE (0.55) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL15906120 0.87 ACHE (0.52) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL4925801 0.86 CYP1A1 (0.69) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL14003485 0.86 MAPT (0.49) CYP3A4ALDH1A1SMN1; SMN2KDM4ENPC1
SCHEMBL277912 0.84 ACHE (0.57) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL18087597 0.84 SMARCA2 (0.46) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL18087562 0.84 MAOB (0.53) ACHEHDAC4HDAC2HDAC8MAOB
SCHEMBL18087565 0.84 LMNA (0.58) ACHECYP3A4HDAC4HDAC2HDAC8
SCHEMBL30112655 0.83 CYP3A4 (0.69) ACHECYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL1673262 0.82 PTGDR2 (0.58) ACHECYP3A4MAOBALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3066072-B1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS UNIV KANSAS (US) 2021-11-03 EP disclosed
EP-2438078-B1 NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES UNIV KANSAS (US) 2017-10-25 EP disclosed
US-20160289217-A1 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS UNIVERSITY OF KANSAS (US) 2016-10-06 US disclosed
US-20160272584-A1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS UNIVERSITY OF KANSAS (US) 2016-09-22 US disclosed
US-9120774-B2 Novobiocin analogues having modified sugar moieties UNIVERSITY OF KANSAS (US) 2015-09-01 US disclosed
WO-2015070091-A1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS THE UNIVERSITY OF KANSAS (US) 2015-05-14 WO disclosed
WO-2015070238-A2 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS THE UNIVERSITY OF KANSAS (US) 2015-05-14 WO disclosed
US-20120252745-A1 NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-10-04 US disclosed
US-8212012-B2 Novobiocin analogues having modified sugar moieties UNIVERSITY OF KANSAS (US) 2012-07-03 US disclosed
WO-2011041593-A1 NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE UNIVERSITY OF KANSAS (US) 2011-04-07 WO disclosed
WO-2010096650-A1 NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES UNIVERSITY OF KANSAS (US) 2010-08-26 WO disclosed
US-20090163709-A1 Novobiocin Analogues Having Modified Sugar Moieties NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090163709-A1 Novobiocin Analogues Having Modified Sugar Moieties HSP90AB1, HSP90B1, HSP90AB2P ACHE 4641/4885CYP1A1 4388/4885CYP1A2 4367/4885
US-20160289217-A1 COUMARIN BASED HSP90 INHIBITORS WITH UREA AND ETHER SUBSTITUENTS HSP90B1, HSP90AA1, HSP90AB1 ACHE 4046/4885CYP1A1 205/4885CYP1A2 525/4885
US-20120252745-A1 NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES HSP90AB1, HSP90AB2P, HSP90B1 ACHE 4861/4885CYP1A1 3699/4885CYP1A2 3257/4885
US-20160272584-A1 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS HSP90AB1, HSP90AA1, HSP90AB2P ACHE 4813/4885CYP1A1 84/4885CYP1A2 222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.