Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869111 | 0.94 | TSHR (0.62) | TSHRLTA4HGPBAR1PLA2G4BCYSLTR2 | |
| SCHEMBL7614389 | 0.90 | KMT2A (0.54) | TSHRGPBAR1CYSLTR1CYP1A2CYP2C19 | |
| SCHEMBL4397448 | 0.90 | TSHR (0.63) | TSHRLTA4HGPBAR1PLA2G4BCYSLTR2 | |
| SCHEMBL8155382 | 0.88 | SMN1; SMN2 (0.50) | TSHRCYP1A2CYP2C19SMN1; SMN2CYP2D6 | |
| SCHEMBL5726997 | 0.86 | MAPK1 (0.56) | TSHRLTA4HCYP1A2CYP2C19KMT2A | |
| 1-Butyloxy-3-Propoxybenzene SCHEMBL3390925 | 0.86 | TSHR (0.59) | TSHRLTA4HGPBAR1PLA2G4BCYSLTR2 | |
| SCHEMBL13303281 | 0.86 | LTA4H (0.57) | TSHRLTA4HCYP1A2CYP2C19CYP19A1 | |
| SCHEMBL15923561 | 0.85 | TSHR (0.65) | TSHRLTA4HGPBAR1PLA2G4BKMT2A | |
| SCHEMBL9487103 | 0.84 | LTA4H (0.68) | TSHRLTA4HGPBAR1PLA2G4BCYSLTR2 | |
| 1-Butyloxy-3-Ethoxybenzene SCHEMBL3459049 | 0.84 | MAPK1 (0.62) | TSHRLTA4HGPBAR1PLA2G4BCYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310252-B1 | AS TOPICAL ANAESTHETICS | ASTRAZENECA AB (SE) | 2001-10-30 | — | — | US | disclosed |
| EP-0858445-A1 | NEW (3-ALKOXY-PHENOXY)-ETHYL]-DIALKYLAMINE DERIVATIVES AND THEIR USE AS LOCAL ANAESTHETICS | Astra Aktiebolag (SE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015548-A1 | NEW [(3-ALKOXY-PHENOXY)-ETHYL]-DIALKYLAMINE DERIVATIVES AND THEIR USE AS LOCAL ANAESTHETICS | ASTRA AKTIEBOLAG (SE) | 1997-05-01 | — | — | WO | disclosed |