Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869218 | 0.88 | REN (0.41) | RENKCNH2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL10202444 | 0.87 | REN (0.47) | RENKCNH2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL10202459 | 0.84 | REN (0.47) | RENKCNH2CYP3A4 | |
| SCHEMBL10202445 | 0.82 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL7863962 | 0.82 | HTR2A (0.43) | RENKCNH2 | |
| SCHEMBL7872527 | 0.82 | REN (0.61) | RENKCNH2CYP3A4CHRM3 | |
| SCHEMBL10202454 | 0.74 | REN (0.51) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL7872583 | 0.74 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL7870962 | 0.73 | REN (0.43) | RENKCNH2CYP3A4 | |
| SCHEMBL7876061 | 0.72 | REN (0.73) | RENKCNH2CYP3A4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |