Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863962 | 0.89 | HTR2A (0.43) | RENHTR2AKCNH2HTR2C | |
| SCHEMBL7862530 | 0.82 | REN (0.63) | RENHTR2AKCNH2HTR2CCYP3A4 | |
| SCHEMBL7869553 | 0.77 | REN (0.71) | RENKCNH2CYP3A4 | |
| SCHEMBL7865848 | 0.77 | REN (0.52) | RENKCNH2CYP3A4HTR1AHTR6 | |
| SCHEMBL7864207 | 0.77 | HTR2A (0.41) | HTR2AHTR2C | |
| SCHEMBL7872529 | 0.76 | REN (0.41) | RENHTR2AKCNH2 | |
| SCHEMBL7865844 | 0.75 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL10202462 | 0.75 | REN (0.47) | RENKCNH2CYP3A4HTR6 | |
| SCHEMBL10202569 | 0.75 | REN (0.76) | RENKCNH2CYP3A4 | |
| SCHEMBL7876082 | 0.73 | REN (0.42) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |