Malonic Acid

Malonic Acid

SCHEMBL7876110

CCOCC.O=C(O)CC(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.56
SRR Q9GZT4 1/20 0.56
FFAR3 O14843 2/20 0.44
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
ALDH1A1 P00352 6/20 0.40
TSHR P16473 2/20 0.40
EGLN1 Q9GZT9 2/20 0.39
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
CYP2D6 P10635 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
ALOX15 P16050 1/20 0.35
SOAT1 P35610 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL3093052 0.86 EGLN1 (0.42) LDHASRRFFAR3MGAMGAA
Propionic Acid SCHEMBL11213569 0.84 FFAR3 (0.67) FFAR3MGAMGAASIMGAM2
Propionic Acid SCHEMBL906439 0.84 FFAR3 (0.67) FFAR3MGAMGAASIMGAM2
Ether SCHEMBL613941 0.83
Ether SCHEMBL9339223 0.83 ALDH1A1 (0.46) FFAR3MGAMGAASIMGAM2
Ether SCHEMBL11351149 0.81 MGAM (0.41) FFAR3MGAMGAASIMGAM2
Ether SCHEMBL251857 0.81 FFAR3 (0.44) FFAR3MGAMGAASIMGAM2
Propionic Acid SCHEMBL21247075 0.81 FFAR3 (0.62) FFAR3MGAMGAASIMGAM2
Succinic Acid SCHEMBL3022051 0.81 LMNA (0.56) FFAR3ALDH1A1TSHREGLN1HDAC3
Ether SCHEMBL20338904 0.80 ALDH1A1 (0.50) FFAR3MGAMGAASIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105669458-B Low VOC/ Diamond Search glycol ether-ester as coalescent 陶氏环球技术有限公司 2019-03-26 CN disclosed
CN-102732077-B Low/zero VOC glycol ether-esters as coalescents for aqueous polymer dispersions 陶氏环球技术有限公司 2017-07-04 CN disclosed
CN-103151561-B Electrolytic lithium salt and preparation method and applications of electrolyte solution containing lithium salt UNIV SOUTH CHINA NORMAL 2015-07-01 CN disclosed
CN-103151561-A Electrolytic lithium salt and preparation method and applications of electrolyte solution containing lithium salt UNIV SOUTH CHINA NORMAL 2013-06-12 CN disclosed
EP-2508572-A1 Low/zero voc glycol ether-esters and use as clean-up solvents and paint thinners Dow Global Technologies LLC (US) 2012-10-10 EP disclosed
EP-0820433-B1 O-MALONYLTYROSYL COMPOUNDS, O-MALONYLTYROSYL COMPOUND-CONTAINING PEPTIDES, AND USES THEREOF US GOV HEALTH & HUMAN SERV (US) 2001-10-24 EP disclosed
CN-1290249-A Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-04-04 CN disclosed
EP-0820433-A1 O-MALONYLTYROSYL COMPOUNDS, O-MALONYLTYROSYL COMPOUND-CONTAINING PEPTIDES, AND USES THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-01-28 EP disclosed
US-5688992-A COMPOUNDS FOR TREATMENT OF SIGNALING PATHWAYS IN IMMUNE DISFUNCTION, CANCER AND DIABETES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-11-18 US disclosed
WO-1996030332-A1 O-MALONYLTYROSYL COMPOUNDS, O-MALONYLTYROSYL COMPOUND-CONTAINING PEPTIDES, AND USES THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTHA ND HUMAN SERVICES (US) 1996-10-03 WO disclosed