Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KIF5B | P33176 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ETV6 | P41212 | 1/20 | 0.34 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240085 | 0.94 | MTOR (0.39) | MTORRPTORMLST8JAK3KCNH2 | |
| SCHEMBL10240007 | 0.92 | MTOR (0.45) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL10240033 | 0.90 | MTOR (0.39) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL10238211 | 0.90 | MTOR (0.39) | MTORRPTORMLST8JAK3GPR119 | |
| SCHEMBL7885321 | 0.90 | MTOR (0.39) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL10240093 | 0.87 | MTOR (0.38) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL10240030 | 0.86 | MTOR (0.39) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL7880980 | 0.86 | HPGD (0.37) | MTORRPTORMLST8KCNH2RET | |
| SCHEMBL10240029 | 0.85 | MTOR (0.35) | MTORRPTORMLST8RETKIF5B | |
| SCHEMBL10234991 | 0.85 | MTOR (0.38) | MTORRPTORMLST8JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |