Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.34 |
| ▸ | BTK | Q06187 | 5/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240082 | 0.90 | PDE4A (0.35) | ALDH1A1MTORRPTORMLST8RAB9A | |
| SCHEMBL7883963 | 0.89 | HPGD (0.37) | HPGDTSHRGAAALDH1A1KDR | |
| SCHEMBL10240007 | 0.89 | MTOR (0.45) | KDRMTORRPTORMLST8RET | |
| SCHEMBL10240033 | 0.86 | MTOR (0.39) | KDRMTORRPTORMLST8RET | |
| SCHEMBL7876256 | 0.86 | MTOR (0.40) | KDRMTORRPTORMLST8RET | |
| SCHEMBL7885321 | 0.86 | MTOR (0.39) | HPGDTSHRALDH1A1KDRMTOR | |
| SCHEMBL10240093 | 0.86 | MTOR (0.38) | KDRMTORRPTORMLST8SCD5 | |
| SCHEMBL10240029 | 0.86 | MTOR (0.35) | KDRMTORRPTORMLST8RET | |
| SCHEMBL10240030 | 0.85 | MTOR (0.39) | HPGDALDH1A1KDRMTORRPTOR | |
| SCHEMBL10240085 | 0.85 | MTOR (0.39) | KDRMTORRPTORMLST8RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |