Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | KIF5B | P33176 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | ETV6 | P41212 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CCDC6 | Q16204 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240030 | 0.93 | MTOR (0.39) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10240007 | 0.92 | MTOR (0.45) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7876256 | 0.90 | MTOR (0.40) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7885321 | 0.90 | MTOR (0.39) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10234899 | 0.90 | MTOR (0.38) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10240029 | 0.89 | MTOR (0.35) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10240085 | 0.89 | MTOR (0.39) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10240093 | 0.87 | MTOR (0.38) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7880980 | 0.86 | HPGD (0.37) | MTORRPTORMLST8RETKDR | |
| SCHEMBL10240082 | 0.85 | PDE4A (0.35) | MTORRPTORMLST8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885RPTOR 3/4885MLST8 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.