Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IL6 | P05231 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28855680 | 0.82 | SMN1; SMN2 (0.39) | NOS1NOS3SMN1; SMN2NOS2TAAR1 | |
| SCHEMBL10701891 | 0.75 | TAAR1 (0.36) | NOS1NOS3SMN1; SMN2NOS2TAAR1 | |
| SCHEMBL11150461 | 0.74 | NOS3 (0.39) | NOS1NOS3SMN1; SMN2NOS2TAAR1 | |
| SCHEMBL1264561 | 0.74 | TLR8 (0.33) | NOS1NOS3NOS2TLR8TLR7 | |
| SCHEMBL23861145 | 0.73 | NOS1 (0.46) | NOS1HTR6HTR7 | |
| SCHEMBL1642010 | 0.73 | NOS1 (0.43) | NOS1NOS3NOS2TAAR1RAD52 | |
| SCHEMBL31018499 | 0.72 | DPP4 (0.41) | NOS1NOS3SMN1; SMN2NOS2TAAR1 | |
| SCHEMBL3872251 | 0.72 | TAAR1 (0.39) | NOS1NOS3SMN1; SMN2NOS2TAAR1 | |
| SCHEMBL6111658 | 0.72 | KCNH2 (0.41) | NOS1NOS3NOS2TAAR1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL3425848 | 0.71 | NOS1 (0.42) | NOS1NOS3SMN1; SMN2NOS2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |