Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13689124 | 0.83 | FFAR2 (0.57) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL11174268 | 0.83 | FFAR2 (0.57) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL11174264 | 0.83 | FFAR2 (0.57) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11188560 | 0.81 | FFAR2 (0.56) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11186377 | 0.81 | FFAR2 (0.56) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Bromide SCHEMBL11193140 | 0.81 | FFAR2 (0.56) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Bromide SCHEMBL11193137 | 0.81 | FFAR2 (0.56) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL1107001 | 0.78 | LMNA (0.62) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11189717 | 0.78 | FFAR2 (0.52) | FFAR2LMNAALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL11189725 | 0.78 | FFAR2 (0.52) | FFAR2LMNAALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |