Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876929 | 0.85 | POLB (0.63) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL7877016 | 0.85 | POLB (0.63) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3890657 | 0.80 | POLB (0.57) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6793174 | 0.80 | POLB (0.69) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6799235 | 0.80 | POLB (0.69) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6795826 | 0.80 | POLB (0.69) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL2666190 | 0.78 | ALDH1A1 (0.71) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL8889475 | 0.76 | POLB (0.52) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL8889472 | 0.76 | POLB (0.52) | POLBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL13995141 | 0.75 | POLB (0.58) | POLBALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |