Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11635572 | 0.82 | KMT2A (0.59) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL29029414 | 0.80 | PTGS2 (0.66) | SMN1; SMN2ALDH1A1PTGS2HTTLMNA | |
| SCHEMBL2516053 | 0.78 | KDM4E (0.69) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL31658991 | 0.78 | KMT2A (0.83) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL9341104 | 0.78 | KMT2A (0.83) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL14452046 | 0.78 | KMT2A (0.71) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL31188516 | 0.78 | KMT2A (0.71) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL7874821 | 0.77 | ALDH1A1 (0.62) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 | |
| SCHEMBL12505347 | 0.77 | NPC1 (0.57) | SMN1; SMN2ALDH1A1PTGS2HTTLMNA | |
| SCHEMBL1503134 | 0.76 | KMT2A (0.65) | KMT2ASMN1; SMN2ALDH1A1EPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616441-A2 | PYRIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma LP (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035421-A2 | PYRIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (US) | 2012-03-22 | — | — | WO | disclosed |