SCHEMBL7876593

SCHEMBL7876593

CC(C)(C)[C@H](N)C(=O)Nc1ccc(N)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CIT O14578 2/20 0.48
KIT P10721 4/20 0.41
EIF2AK3 Q9NZJ5 1/20 0.40
HDAC1 Q13547 3/20 0.39
HDAC3 O15379 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
SPHK1 Q9NYA1 1/20 0.39
BRAF P15056 1/20 0.39
MAPK14 Q16539 2/20 0.38
KDR P35968 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CDK8 P49336 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
ABL1 P00519 1/20 0.38
BCR P11274 1/20 0.38
ALDH1A1 P00352 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27528501 0.83 TAAR1 (0.53) CITKITEIF2AK3HDAC1HDAC3
SCHEMBL7868098 0.77 FFAR2 (0.56) KMT2ASMN1; SMN2
Hydrochloric Acid SCHEMBL7874804 0.76 FFAR2 (0.54) KMT2ASMN1; SMN2
Hydrochloric Acid SCHEMBL7868142 0.76 FFAR2 (0.54) KMT2ASMN1; SMN2
SCHEMBL29403604 0.75 SMN1; SMN2 (0.50) HDAC1MAPK14CA1CA2CA7
SCHEMBL2081651 0.75 SMN1; SMN2 (0.50) HDAC1MAPK14CA1CA2CA7
SCHEMBL7425368 0.74 CIT (0.52) CITCDK8SMN1; SMN2
SCHEMBL6625479 0.74 CIT (0.52) CITCDK8SMN1; SMN2
SCHEMBL31190971 0.74 NAMPT (0.51) KITCA1
SCHEMBL4942948 0.74 NAMPT (0.51) KITCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329400-B1 INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS GLAXO WELLCOME INC. 2001-12-11 US disclosed