Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625479 | 1.00 | CIT (0.52) | CITFFAR2MDM2ROCK2ROCK1 | |
| SCHEMBL30135056 | 0.91 | AAK1 (0.62) | CITFFAR2ROCK2ROCK1AAK1 | |
| SCHEMBL8396733 | 0.82 | MAPT (0.57) | CITLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL7868098 | 0.82 | FFAR2 (0.56) | FFAR2LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7868142 | 0.81 | FFAR2 (0.54) | FFAR2LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7874804 | 0.81 | FFAR2 (0.54) | FFAR2LMNAHTTSMN1; SMN2 | |
| SCHEMBL15432240 | 0.80 | TAAR1 (0.59) | FFAR2MDM2ROCK2ROCK1AAK1 | |
| SCHEMBL7873436 | 0.76 | CIT (0.42) | CITKDM4EL3MBTL1TDP1 | |
| SCHEMBL1911525 | 0.76 | MDM2 (0.59) | FFAR2MDM2ROCK2ROCK1AAK1 | |
| SCHEMBL13690884 | 0.76 | LMNA (0.56) | LMNAHTTKDM4EL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |
| US-5672583-A | Carboxy-peptidyl derivatives as antidegenerative active agents | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0671911-A4 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS. | MERCK & CO INC (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0671911-A1 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO. INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012169-A1 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | disclosed |