Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12881193 | 0.84 | LMNA (0.69) | KMT2ALMNAKDM4ECDK4CCND1 | |
| SCHEMBL2593474 | 0.83 | KMT2A (0.65) | KMT2ANTSR1LMNAIDO1CDK4 | |
| SCHEMBL3307080 | 0.82 | KMT2A (0.68) | KMT2ANTSR1LMNAKDM4EIDO1 | |
| SCHEMBL5051883 | 0.81 | LMNA (0.61) | KMT2ALMNACDK4CCND1MAPK1 | |
| SCHEMBL29955957 | 0.81 | KMT2A (0.71) | KMT2ANTSR1LMNAIDO1CDK4 | |
| SCHEMBL1519806 | 0.81 | KMT2A (0.71) | KMT2ANTSR1LMNAIDO1CDK4 | |
| SCHEMBL6138108 | 0.80 | KMT2A (0.69) | KMT2ANTSR1LMNAKDM4EIDO1 | |
| SCHEMBL12605550 | 0.80 | KMT2A (0.59) | KMT2ANTSR1LMNAKDM4EIDO1 | |
| SCHEMBL29035968 | 0.80 | KDM4E (0.52) | KMT2ALMNAKDM4ENPC1HSD17B10 | |
| SCHEMBL1598786 | 0.79 | KMT2A (1.00) | KMT2ANTSR1LMNAKDM4ECDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772592-A4 | 1H-INDOLE-1-FUNCTIONAL sPLA 2? INHIBITORS | LILLY CO ELI (US) | 1998-07-08 | — | — | EP | claimed |
| US-5641800-A | ALLEVIATE EFFECT OF SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, AND RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY (US) | 1997-06-24 | — | — | US | claimed |
| EP-0772592-A1 | 1H-INDOLE-1-FUNCTIONAL sPLA 2? INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | claimed |
| WO-1996003376-A1 | 1H-INDOLE-1-FUNCTIONAL sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | claimed |
| US-6325991-B1 | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 | DRAHEIM SUSAN E (US) | 2001-12-04 | — | — | US | disclosed |