Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903959 | 0.73 | ACE (0.53) | ACESLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7879178 | 0.71 | ACE (0.39) | ACESLC1A3SLC1A2SLC1A1PTGS2 | |
| SCHEMBL7879214 | 0.66 | SLC1A3 (0.49) | ACESLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL4308700 | 0.63 | POLB (0.40) | SLC1A3SLC1A2SLC1A1POLBPTGS2 | |
| SCHEMBL6362101 | 0.61 | SLC15A1 (0.50) | ACESLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL11210664 | 0.61 | CYP1A2 (0.53) | ACE | |
| SCHEMBL17171334 | 0.61 | CYP1A2 (0.53) | ACE | |
| SCHEMBL17171335 | 0.61 | CYP1A2 (0.53) | ACE | |
| SCHEMBL7876539 | 0.61 | SMN1; SMN2 (0.46) | ACESLC1A3SLC1A2SLC1A1POLB | |
| Hydrochloric Acid SCHEMBL4864811 | 0.60 | SLC15A1 (0.49) | ACESLC1A3SLC1A2SLC1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |