Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | TLL1 | O43897 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877013 | 0.77 | ACE (0.37) | ACEPTPN1HPGD | |
| SCHEMBL7873420 | 0.75 | BMP1 (0.39) | KMT2AMEN1PTPN2PTPN1DUSP3 | |
| SCHEMBL7876860 | 0.74 | BMP1 (0.40) | KMT2AMEN1PTPN2PTPN1DUSP3 | |
| SCHEMBL7903959 | 0.74 | ACE (0.53) | ACESLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7876858 | 0.72 | SLC1A3 (0.37) | KMT2AMEN1PTPN2PTPN1DUSP3 | |
| SCHEMBL7879214 | 0.71 | SLC1A3 (0.49) | ACESLC1A3SLC1A2SLC1A1TLL1 | |
| SCHEMBL7876890 | 0.71 | ACE (0.38) | ACEKMT2AMEN1SLC1A3SLC1A2 | |
| SCHEMBL7876539 | 0.69 | SMN1; SMN2 (0.46) | ACEKMT2AMEN1SLC1A3SLC1A2 | |
| SCHEMBL7387885 | 0.66 | TLL1 (0.42) | ACETLL1BMP1MMP12TLL2 | |
| SCHEMBL7868080 | 0.66 | TLL1 (0.43) | TLL1BMP1MMP12TLL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |