Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.49 |
| ▸ | RXRB | P28702 | 11/20 | 0.49 |
| ▸ | RXRG | P48443 | 10/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 7/20 | 0.41 |
| ▸ | RARG | P13631 | 7/20 | 0.41 |
| ▸ | RARA | P10276 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881559 | 1.00 | RXRA (0.49) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL7883321 | 0.90 | RXRA (0.53) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL8349950 | 0.88 | RXRA (0.39) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL8352422 | 0.88 | RXRA (0.39) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL8353225 | 0.88 | RXRA (0.39) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL8350408 | 0.88 | RXRA (0.39) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL8347375 | 0.86 | RXRA (0.40) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL7881549 | 0.81 | RXRA (0.50) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL7876901 | 0.81 | RXRA (0.50) | RXRARXRBRXRGHNF4ACYP26A1 | |
| SCHEMBL7876764 | 0.81 | RXRA (0.50) | RXRARXRBRXRGHNF4ACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6171603-B1 | TREATING SKIN, HAIR, CARDIOVASCULAR, AUTOIMMUNE AND VISION DISORDERS; ADMINISTERING AS ANTICARCINOGENIC, ANTIDEPRESSANT,ANTIINFLAMMATORY, AND ANTIACNE AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-01-09 | — | — | US | claimed |
| EP-0728739-B1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CIRD GALDERMA (FR) | 1997-11-05 | — | — | EP | claimed |
| US-6171603-B1 | TREATING SKIN, HAIR, CARDIOVASCULAR, AUTOIMMUNE AND VISION DISORDERS; ADMINISTERING AS ANTICARCINOGENIC, ANTIDEPRESSANT,ANTIINFLAMMATORY, AND ANTIACNE AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-01-09 | — | — | US | disclosed |