SCHEMBL8347375 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	RXRA	P19793	16/20	0.40

▸	RXRB	P28702	12/20	0.40

▸	RXRG	P48443	12/20	0.40

▸	CYP26A1	O43174	1/20	0.36

▸	CYP3A4	P08684	1/20	0.36

▸	CYP26B1	Q9NR63	1/20	0.36

▸	HNF4A	P41235	1/20	0.35

▸	PPARG	P37231	1/20	0.34

▸	NR1H3	Q13133	1/20	0.34

▸	PTPN1	P18031	2/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	PTPRA	P18433	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8352422	0.99	RXRA (0.39)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8353225	0.99	RXRA (0.39)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8350408	0.99	RXRA (0.39)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8349950	0.99	RXRA (0.39)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8347055	0.91	RXRA (0.43)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8346572	0.89	RXRA (0.40)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8347637	0.87	RXRA (0.41)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL7876892	0.86	RXRA (0.49)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL7881559	0.86	RXRA (0.49)	RXRARXRBRXRGCYP26A1CYP3A4
SCHEMBL8351713	0.86	RXRA (0.38)	RXRARXRBRXRGCYP26A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5935585-A	Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof	CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR)	1999-08-10	—	—	US	disclosed