Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.31 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL439676 | 1.00 | TSHR (0.59) | TSHRMAPK1KMT2AMEN1CA5A | |
| Di(Hydroxyethyl)Ether SCHEMBL10582766 | 1.00 | TSHR (0.59) | TSHRMAPK1KMT2AMEN1CA5A | |
| Triethylene Glycol SCHEMBL989878 | 0.97 | KMT2A (0.61) | TSHRMAPK1KMT2AMEN1CA5A | |
| Triethylene Glycol SCHEMBL6292167 | 0.97 | KMT2A (0.61) | TSHRMAPK1KMT2AMEN1CA5A | |
| Tetraethylene Glycol SCHEMBL1773960 | 0.97 | KMT2A (0.61) | TSHRMAPK1KMT2AMEN1CA5A | |
| Triethylene Glycol SCHEMBL10582059 | 0.97 | KMT2A (0.61) | TSHRMAPK1KMT2AMEN1CA5A | |
| Di(Hydroxyethyl)Ether SCHEMBL27621023 | 0.86 | TSHR (0.43) | TSHRMAPK1KMT2AMEN1CA5A | |
| Di(Hydroxyethyl)Ether SCHEMBL28257194 | 0.86 | TSHR (0.56) | TSHRMAPK1KMT2AMEN1CA5A | |
| 2-Ethoxyethanol SCHEMBL10613720 | 0.85 | ALDH1A1 (0.67) | TSHRMAPK1KMT2AMEN1CA5A | |
| SCHEMBL4372008 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122070479-A | Ultrasonic indicating device and method for monitoring ultrasonic treatment | JP实验室股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-113233945-B | Preparation method of smokeless propellant for fireworks | 湖南恒达烟花有限公司 | 2022-05-31 | — | — | CN | claimed |
| CN-113357969-A | Fireworks are touched off in high altitude with waterproof function | 湖南恒达烟花有限公司 | 2021-09-07 | — | — | CN | claimed |
| CN-113233945-A | Smokeless propellant for fireworks | 湖南恒达烟花有限公司 | 2021-08-10 | — | — | CN | claimed |
| CN-109134168-A | A kind of preparation method of the uniform azide polyethers system of extremely low solid content | 上海航天化工应用研究所 | 2019-01-04 | — | — | CN | claimed |
| US-8292976-B2 | Diesel fuel additive for reducing emissions | AFTON CHEMICAL CORPORATION (US) | 2012-10-23 | — | — | US | claimed |
| US-20120066964-A1 | Additives for Reduction of Exhaust Emissions from Compression Ignition Engines | BAKER HUGHES INCORPORATED (US) | 2012-03-22 | — | — | US | claimed |
| US-20110107658-A1 | DIESEL FUEL ADDITIVE FOR REDUCING EMISSIONS | AFTON CHEMICAL CORPORATION (US) | 2011-05-12 | — | — | US | claimed |
| US-20100325944-A1 | Additives for Cetane Improvement in Middle Distillate Fuels | BAKER HUGHES INCORPORATED (US) | 2010-12-30 | — | — | US | claimed |
| WO-2008150950-A1 | ADDITIVES FOR REDUCTION OF EXHAUST EMISSIONS FROM COMPRESSION IGNITION ENGINES | BAKER HUGHES INCORPORATED (US) | 2008-12-11 | — | — | WO | claimed |
| US-20080295395-A1 | Additives for Reduction of Exhaust Emissions From Compression Ignition Engines | BAKER HUGHES INCORPORATED (US) | 2008-12-04 | — | — | US | claimed |
| CN-122070479-A | Ultrasonic indicating device and method for monitoring ultrasonic treatment | JP实验室股份有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-113233945-B | Preparation method of smokeless propellant for fireworks | 湖南恒达烟花有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-113233945-B | Preparation method of smokeless propellant for fireworks | 湖南恒达烟花有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-113357969-A | Fireworks are touched off in high altitude with waterproof function | 湖南恒达烟花有限公司 | 2021-09-07 | — | — | CN | disclosed |
| EP-0223440-B1 | A PROCESS FOR THE PRODUCTION OF HIGH ENERGY MATERIAL | The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and (GB) | 1991-03-06 | — | — | EP | disclosed |
| US-4985584-A | RING OPENING REACTION WITH N2O4 OR N2O5 | SECRETARY OF STATE FOR DEFENCE (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4932980-A | SOLVENT AND GRAFT POLYMER OF ETHYLENE, VINYL ACETATE AND METHACRYLIC ACID ESTERS | ROHM GMBH (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4718953-A | High explosive compound in nitrate salt matrix | C-I-L INC. (CA) | 1988-01-12 | — | — | US | disclosed |
| EP-0223440-A1 | A process for the production of high energy material | The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and (GB) | 1987-05-27 | — | — | EP | disclosed |