Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | FLT4 | P35916 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885975 | 0.86 | KDR (0.41) | KDRPDGFRAPDGFRBFLT3CSF1R | |
| SCHEMBL5566432 | 0.81 | KDR (0.44) | KDRPDGFRAPDGFRBFLT3CSF1R | |
| SCHEMBL5566766 | 0.78 | EGFR (0.43) | KDRPDGFRBFLT4KITRAF1 | |
| SCHEMBL5565927 | 0.74 | KDM1A (0.54) | KDRPDGFRAPDGFRBFLT3CSF1R | |
| SCHEMBL5566455 | 0.73 | EGFR (0.53) | KDRKITEGFR | |
| SCHEMBL5561051 | 0.71 | FLT4 (0.52) | KDRPDGFRAPDGFRBFLT3CSF1R | |
| SCHEMBL5566781 | 0.71 | EGFR (0.50) | KDRPDGFRBFLT3CSF1RFLT4 | |
| SCHEMBL5566618 | 0.70 | KDR (0.61) | KDRPDGFRAPDGFRBFLT3CSF1R | |
| SCHEMBL7881690 | 0.70 | EGFR (0.48) | KDRFLT4EGFR | |
| SCHEMBL7853443 | 0.69 | KDM1A (0.44) | KDRPDGFRAPDGFRBFLT3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |