Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.47 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 6/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | FLT4 | P35916 | 5/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883378 | 0.93 | EGFR (0.48) | EGFRKDRRETSRCFLT1 | |
| SCHEMBL7881690 | 0.93 | EGFR (0.48) | EGFRKDRRETLCKSRC | |
| SCHEMBL7883417 | 0.89 | EGFR (0.51) | EGFRKDRRETAURKAFLT1 | |
| SCHEMBL7882903 | 0.89 | KDR (0.47) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL7887944 | 0.86 | EGFR (0.62) | EGFRKDRRETLCKFLT1 | |
| Hydrochloric Acid SCHEMBL5561522 | 0.85 | EGFR (0.63) | EGFRKDRRETLCKFLT1 | |
| SCHEMBL5567690 | 0.78 | EGFR (0.73) | EGFRKDR | |
| Hydrochloric Acid SCHEMBL6444589 | 0.77 | EGFR (0.72) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL5649183 | 0.77 | EGFR (0.62) | EGFRKDRRETSRCFLT1 | |
| SCHEMBL2200924 | 0.75 | KDR (0.74) | EGFRKDRRETLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |