Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.48 |
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | FLT1 | P17948 | 5/20 | 0.48 |
| ▸ | FLT4 | P35916 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881690 | 0.93 | EGFR (0.48) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7876965 | 0.93 | EGFR (0.47) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7882903 | 0.90 | KDR (0.47) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7883417 | 0.85 | EGFR (0.51) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL2200924 | 0.80 | KDR (0.74) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5565975 | 0.78 | EGFR (0.68) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7887944 | 0.77 | EGFR (0.62) | EGFRKDRFLT1KDM4EHTT | |
| SCHEMBL5649183 | 0.76 | EGFR (0.62) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL5561522 | 0.76 | EGFR (0.63) | EGFRKDRFLT1KDM4EHTT | |
| SCHEMBL7885975 | 0.76 | KDR (0.41) | EGFRKDRFLT4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |