Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5561522 | 0.99 | EGFR (0.63) | EGFRKDRRETLCKKDM4E | |
| SCHEMBL7876965 | 0.86 | EGFR (0.47) | EGFRKDRRETLCKKDM4E | |
| SCHEMBL5567690 | 0.85 | EGFR (0.73) | EGFRKDR | |
| Hydrochloric Acid SCHEMBL6444589 | 0.84 | EGFR (0.72) | EGFRKDRFLT1 | |
| SCHEMBL8704247 | 0.78 | EGFR (0.63) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL1257431 | 0.78 | EGFR (1.00) | EGFRKDRRETLCKKDM4E | |
| SCHEMBL29515328 | 0.78 | EGFR (1.00) | EGFRKDRRETLCKKDM4E | |
| Hydrochloric Acid SCHEMBL8814111 | 0.77 | EGFR (0.85) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL7883378 | 0.77 | EGFR (0.48) | EGFRKDRRETKDM4EHTT | |
| SCHEMBL7881690 | 0.77 | EGFR (0.48) | EGFRKDRRETLCKRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |