Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718998 | 0.75 | MAPT (0.52) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL2713154 | 0.73 | KDM4E (0.59) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL2718370 | 0.72 | SYK (0.53) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL29896827 | 0.72 | BTK (0.46) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL4584445 | 0.72 | MAPT (0.55) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL4414124 | 0.72 | PARP1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL29908356 | 0.72 | PARP1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL30470502 | 0.72 | PRMT5 (0.49) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL30469627 | 0.71 | PRMT5 (0.41) | ALDH1A1KDM4EHPGDHSD17B10RAB9A | |
| SCHEMBL30471109 | 0.71 | PRMT5 (0.41) | ALDH1A1KDM4EHPGDHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |