SCHEMBL4414124

SCHEMBL4414124

NC(=O)c1cccnc1C1CCCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.46
CDC7 O00311 1/20 0.44
KDM4E B2RXH2 4/20 0.43
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MAPT P10636 3/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
AHR P35869 1/20 0.42
HTT P42858 1/20 0.41
TP53 P04637 1/20 0.41
DDB1 Q16531 1/20 0.41
CRBN Q96SW2 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29908356 1.00 PARP1 (0.46) PARP1CDC7KDM4EALDH1A1GAA
SCHEMBL3427703 0.98 PARP1 (0.47) PARP1CDC7KDM4EALDH1A1GAA
SCHEMBL3427967 0.95 PARP1 (0.47) PARP1CDC7KDM4EALDH1A1GAA
SCHEMBL2395933 0.92 PARP1 (0.50) PARP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL28059195 0.85 KDM4E (0.51) KDM4EALDH1A1GAAMAPTRAB9A
SCHEMBL5083476 0.84 OPRL1 (0.46) PARP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL3963175 0.83 P2RX7 (0.53) KDM4EALDH1A1GAARAB9AMEN1
SCHEMBL3955549 0.82 PARP1 (0.52) PARP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL30767818 0.81 MAPT (0.48) KDM4EALDH1A1GAAHPGDHSD17B10
SCHEMBL29373648 0.81 ALDH1A1 (0.42) PARP1KDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3774739-B1 FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST RAQUALIA PHARMA INC (JP) 2022-05-11 EP claimed
EP-1651609-A1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS Pfizer Limited (GB) 2006-05-03 EP claimed
WO-2005009966-A1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS PFIZER LIMITED (GB) 2005-02-03 WO claimed
EP-3731869-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2020-11-04 EP disclosed
CN-109705097-A Indazole -3- carboxylic acid amides and its purposes as WNT/ β-CATENIN signal transduction pathway inhibitor 萨穆梅德有限公司 2019-05-03 CN disclosed
CN-109641871-A AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS 诺华股份有限公司 2019-04-16 CN disclosed
CN-104334527-B Sulfonamide compounds and uses as tnap inhibitors 桑福德-伯纳姆医学研究院 2017-05-24 CN disclosed
WO-2009153720-A1 NICOTINAMIDE DERIVATIVES PFIZER LIMITED (GB) 2009-12-23 WO disclosed
EP-1740544-A1 2-PYRIDINYLCYCLOALKYLCARBOXAMIDE DERIVATIVES USEFUL AS FUNGICIDES Bayer CropScience S.A. (FR) 2007-01-10 EP disclosed
WO-2006068410-A1 NOVEL 3-(2-AMINO-6-PYRIDINYL)-4-HYDROXYPHENYL AMINE DERIVATIVES LG LIFE SCIENCES, LTD. (KR) 2006-06-29 WO disclosed
WO-2005103006-A1 2-PYRIDINYLCYCLOALKYLCARBOXAMIDE DERIVATIVES USEFUL AS FUNGICIDES BAYER CROPSCIENCE SA (FR) 2005-11-03 WO disclosed
WO-2003068233-A1 NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES PFIZER LIMITED (GB) 2003-08-21 WO disclosed