Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.63 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12774613 | 0.89 | MTOR (0.66) | MTORPIK3CA | |
| SCHEMBL12728216 | 0.78 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL12773005 | 0.74 | MTOR (0.63) | MTORFYNMAP4K4 | |
| SCHEMBL7879341 | 0.73 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL12773635 | 0.72 | MTOR (0.66) | MTORPTGS2PIK3CAPTGS1FYN | |
| SCHEMBL12137944 | 0.70 | MTOR (0.48) | MTORDHFRPIK3CA | |
| SCHEMBL12774612 | 0.69 | MTOR (0.69) | MTORPIK3CA | |
| SCHEMBL12774560 | 0.69 | MTOR (0.66) | MTORPTGS2DYRK1BPTGS1FYN | |
| SCHEMBL5350907 | 0.69 | PTGS2 (0.63) | PTGS2PIK3CAPTGS1FYNMAP4K4 | |
| SCHEMBL12138131 | 0.69 | PTGS2 (0.46) | MTORDHFRPTGS2PIK3CAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098275-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | US | disclosed |
| WO-2010122069-A1 | 5-ALKYNYL-PYRIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098275-A1 | 5-ALKYNYL-PYRIDINES | MKI67, KIT, CCNA1 | MTOR 1220/4885DHFR 100/4885PTGS2 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.