Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029364 | 0.85 | CA2 (0.61) | PTGS2PTGS1MKNK1MKNK2MAP4K4 | |
| SCHEMBL27928727 | 0.84 | MKNK1 (0.53) | PTGS2PTGS1MKNK1MKNK2MAP4K4 | |
| SCHEMBL15730118 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1MKNK1MKNK2DRD1 | |
| SCHEMBL29964465 | 0.83 | MKNK1 (0.51) | PTGS2PTGS1MKNK1MKNK2MAP4K4 | |
| SCHEMBL15408950 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1MKNK1MKNK2MAP4K4 | |
| SCHEMBL25339185 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1DRD1 | |
| SCHEMBL6170026 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1DRD1 | |
| SCHEMBL14555904 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1DRD1 | |
| SCHEMBL8442044 | 0.78 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL1826205 | 0.78 | PTGS2 (0.60) | PTGS2PTGS1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102812006-B | Novel antimalaria reagent | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-01-20 | — | — | CN | claimed |
| CN-102812006-B | Novel antimalaria reagent | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-01-20 | — | — | CN | disclosed |
| WO-2007129169-A2 | COX- II INHIBITORS FOR IMPROVING REPRODUCTIVE SUCCESS IN A FEMALE ANIMAL | PFIZER LIMITED (GB) | 2007-11-15 | — | — | WO | disclosed |
| EP-1282423-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | Oklahoma Medical Research Foundation (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20030017148-A1 | Prevention of insulin-dependent diabetes, complications thereof, or allograft rejection by inhibition of cyclooxygenase-2 activity | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2003-01-23 | — | — | US | disclosed |
| WO-2001085175-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2001-11-15 | — | — | WO | disclosed |