SCHEMBL7877641

SCHEMBL7877641

CCN(CC)CCCOc1ccc(OC(C)C)c2cc(C(=O)N(C)C(=N)N)[nH]c12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.34
ALDH1A1 P00352 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
MAOB P27338 3/20 0.34
HRH3 Q9Y5N1 3/20 0.33
ACHE P22303 3/20 0.32
CYP1A2 P05177 2/20 0.32
CYP2D6 P10635 2/20 0.32
SCN1A P35498 2/20 0.32
KCNH2 Q12809 2/20 0.32
SCN2A Q99250 2/20 0.32
SCN3A Q9NY46 2/20 0.32
CYP3A4 P08684 1/20 0.32
MAOA P21397 1/20 0.32
CYP2C19 P33261 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7884646 0.92 KDM4E (0.39) KDM4EALDH1A1TDP1HRH3CYP1A2
SCHEMBL7881940 0.90 KDM4E (0.43) KDM4EALDH1A1TDP1ACHEHPGD
SCHEMBL7877498 0.89 KDM4E (0.34) KDM4EALDH1A1GAAHPGD
SCHEMBL7879681 0.88 ALDH1A1 (0.38) KDM4EALDH1A1TDP1MAOBHRH3
Hydrochloric Acid SCHEMBL7881259 0.88 POLB (0.34) KDM4EALDH1A1HPGD
Hydrochloric Acid SCHEMBL7884697 0.87 ALDH1A1 (0.38) KDM4EALDH1A1TDP1MAOBHRH3
Hydrochloric Acid SCHEMBL7884821 0.87 KDM4E (0.39) KDM4EALDH1A1TDP1MAOBHRH3
SCHEMBL7879687 0.83 ALDH1A1 (0.40) KDM4EALDH1A1MAOBHRH3MEN1
SCHEMBL7884728 0.83 ULK1 (0.44) KDM4EALDH1A1MAOBHRH3ACHE
SCHEMBL7877560 0.81 HTR1B (0.39) KDM4EALDH1A1TDP1MAOBBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248772-B1 HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2001-06-19 US disclosed
US-6169107-B1 USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS SUMITOMO PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-0622356-B1 Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange SUMITOMO PHARMA (JP) 1998-07-01 EP disclosed
EP-0708091-A2 Indoloylguanidine derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-04-24 EP disclosed
EP-0622356-A1 Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1994-11-02 EP disclosed