Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.58 |
| ▸ | TK2 | O00142 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877854 | 1.00 | TK1 (0.58) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL6737951 | 0.91 | TK1 (0.64) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL6737955 | 0.91 | TK1 (0.64) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL13412992 | 0.91 | TK1 (0.64) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL8167217 | 0.90 | TK1 (0.62) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL13082855 | 0.84 | LMNA (0.64) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL12060321 | 0.84 | LMNA (0.64) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL7875550 | 0.83 | TK1 (0.68) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL20684355 | 0.83 | TK1 (0.58) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| SCHEMBL7866081 | 0.82 | LMNA (0.53) | TK1TK2LMNASMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6312953-B1 | MODIFIED OLIGONUCLEOTIDE COMPLEMENTARY TO A TARGET SEQUENCE AND HAVING AT LEAST TWO CROSSLINKING AGENTS COVALENTLY ATTATCHED; GENE EXPRESSION INHIBITION; DNA SEQUENCING; GENETIC MAPPING | EPOCH PHARMACEUTICALS, INC. | 2001-11-06 | — | — | US | disclosed |
| EP-0842186-A1 | CROSS-LINKING OLIGONUCLEOTIDES | MICROPROBE CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1996040711-A1 | CROSS-LINKING OLIGONUCLEOTIDES | MICROPROBE CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |