Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.51 |
| ▸ | HTR1B | P28222 | 8/20 | 0.51 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887345 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6925638 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7882795 | 0.83 | HTR1D (0.73) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7161726 | 0.81 | HTR1D (0.75) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7878033 | 0.80 | HTR1D (0.44) | HTR1DHTR2AMAPTSLC6A4HTR2C | |
| Oxalic Acid SCHEMBL6926422 | 0.79 | HTR1D (0.72) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8934383 | 0.78 | HTR1D (0.71) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7885324 | 0.77 | HTR1D (0.42) | HTR1DHTR1BHTR2AMEN1KMT2A | |
| SCHEMBL7887044 | 0.76 | HTR6 (0.61) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7886696 | 0.76 | MAPK14 (0.43) | HTR1DHTR1BHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098892-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005225-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-03 | — | — | WO | disclosed |