Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878501 | 1.00 | CTSL (0.62) | CTSLNPSR1HTTPIK3CAPIK3CB | |
| SCHEMBL29991312 | 1.00 | CTSL (0.62) | CTSLNPSR1HTTPIK3CAPIK3CB | |
| SCHEMBL11567530 | 0.90 | CTSL (0.56) | CTSLNPSR1HTTPIK3CAPIK3CB | |
| SCHEMBL11567532 | 0.90 | CTSL (0.56) | CTSLNPSR1HTTPIK3CAPIK3CB | |
| SCHEMBL20205932 | 0.83 | NPSR1 (0.62) | CTSLNPSR1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13114090 | 0.83 | NPSR1 (0.58) | CTSLNPSR1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL11743822 | 0.80 | PIK3CA (0.43) | CTSLNPSR1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL17018289 | 0.80 | MAPT (0.43) | CTSLNPSR1HTTPIK3CAPIK3CB | |
| SCHEMBL11743813 | 0.80 | PIK3CA (0.43) | CTSLNPSR1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL16997490 | 0.80 | MAPT (0.43) | CTSLNPSR1HTTPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856514-B1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2001-06-13 | — | — | EP | disclosed |
| EP-0856514-A1 | 8-substituted-1,3,8-triazaspiro[4.5]decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-08-05 | — | — | EP | disclosed |
| US-4169097-A | GASTRIC ANTISECRETORY AGENTS | MORTON-NORWICH PRODUCTS, INC. (US) | 1979-09-25 | — | — | US | disclosed |