Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880761 | 0.90 | BRD4 (0.44) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7880703 | 0.87 | BRD4 (0.44) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7880521 | 0.83 | MAPT (0.48) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7883323 | 0.75 | HSF1 (0.46) | BRD4MAPTMAPK1GRM2 | |
| SCHEMBL7878632 | 0.75 | LMNA (0.47) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7880733 | 0.74 | FLT1 (0.41) | BRD4MAPTEGFRITKNPC1 | |
| SCHEMBL7876720 | 0.74 | BRD4 (0.45) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7880695 | 0.73 | CYP3A4 (0.41) | BRD4CYP1A2CYP3A4EGFRGRM2 | |
| SCHEMBL6690431 | 0.73 | BACE1 (0.41) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6677790 | 0.71 | ALDH1A1 (0.47) | KMT2AALDH1A1POLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |