Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 10/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237857 | 0.91 | CHEK1 (0.41) | MTORPIK3CAMAPK7NTRK1KCNH2 | |
| SCHEMBL10234832 | 0.85 | CHEK1 (0.40) | MTORPIK3CANTRK1KCNH2PIM1 | |
| SCHEMBL10234977 | 0.81 | MTOR (0.44) | MTORPIK3CARPTORMLST8 | |
| SCHEMBL10240078 | 0.80 | MTOR (0.43) | MTORPIK3CARPTORMLST8 | |
| SCHEMBL10234815 | 0.80 | CHEK1 (0.44) | MTORPIM1RPTORMLST8 | |
| SCHEMBL10280308 | 0.79 | MTOR (0.43) | MTORPIK3CARPTORMLST8 | |
| SCHEMBL10234867 | 0.79 | RAB9A (0.38) | MTORPIK3CARPTORMLST8 | |
| SCHEMBL10234657 | 0.79 | CHEK1 (0.45) | MTORKCNH2PIM1RPTORMLST8 | |
| SCHEMBL10240026 | 0.78 | RAB9A (0.37) | MTORPIK3CARPTORMLST8 | |
| SCHEMBL10234674 | 0.78 | MTOR (0.41) | MTORPIK3CAKCNH2HTR2BRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |