Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MDM4 | O15151 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150607 | 0.96 | KMT2A (0.36) | DOT1LMDM2KMT2AFLT4KDR | |
| SCHEMBL7878997 | 0.83 | DOT1L (0.35) | DOT1LMDM2KMT2AFLT4KDR | |
| SCHEMBL7878996 | 0.79 | FLT4 (0.34) | FLT4KDRHPGD | |
| SCHEMBL7878987 | 0.79 | KMT2A (0.36) | DOT1LMDM2KMT2AFLT4KDR | |
| SCHEMBL7872971 | 0.78 | FLT4 (0.45) | KMT2AFLT4KDRHPGDTP53 | |
| SCHEMBL13672813 | 0.78 | DOT1L (0.35) | DOT1LKMT2A | |
| SCHEMBL29586099 | 0.76 | KMT2A (0.38) | DOT1LKMT2AOPRD1 | |
| SCHEMBL13672917 | 0.76 | KMT2A (0.38) | DOT1LKMT2AOPRD1 | |
| SCHEMBL24109140 | 0.75 | HPRT1 (0.42) | DOT1LKMT2A | |
| SCHEMBL7872825 | 0.75 | FLT4 (0.47) | FLT4KDRHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316595-B1 | PNA synthesis using a base-labile amino protecting group | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-11-13 | — | — | US | disclosed |
| US-6121418-A | PNA synthesis using a base-labile amino protecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |