Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867762 | 0.93 | PTGS2 (0.48) | PTGS2ALOX5PTGS1CYP2C9CHRNA7 | |
| SCHEMBL7876672 | 0.89 | PTGS2 (0.50) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL7878975 | 0.85 | ALOX5 (0.51) | PTGS2ALOX5PTGS1CYP2C9CHRNA7 | |
| SCHEMBL28746692 | 0.85 | PTGS2 (0.51) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL7874491 | 0.84 | PTGS2 (0.46) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL7867763 | 0.84 | PTGS2 (0.57) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL27528885 | 0.83 | PTGS2 (0.49) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL27552886 | 0.83 | PTGS2 (0.52) | PTGS2ALOX5PTGS1CYP2C9CHRNA7 | |
| SCHEMBL27556744 | 0.83 | PTGS2 (0.51) | PTGS2ALOX5PTGS1CYP2C9 | |
| SCHEMBL7867859 | 0.82 | PTGS2 (0.50) | PTGS2ALOX5PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| CN-1271347-A | 1, 5-diphenylpyrazole derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-10-25 | — | — | CN | disclosed |