Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868339 | 0.83 | BACE1 (0.47) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL12686649 | 0.76 | CYP1A2 (0.57) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL30133013 | 0.76 | CYP1A2 (0.57) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL28811662 | 0.76 | BACE1 (0.41) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL16289408 | 0.76 | BACE1 (0.41) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL24261121 | 0.76 | ALDH1A1 (0.50) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL584342 | 0.76 | BACE1 (0.41) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL845999 | 0.76 | BACE1 (0.50) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL21988901 | 0.76 | MAP4K4 (0.54) | BACE1PDGFRBPDGFRAPDE3BPDE3A | |
| SCHEMBL29975637 | 0.76 | CNR2 (0.43) | BACE1PDGFRBPDGFRAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |