Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868339 | 0.83 | BACE1 (0.47) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL16155308 | 0.76 | ALDH1A1 (0.50) | BACE1PDE3BPDE3ALMNAKDM4E | |
| SCHEMBL7879181 | 0.76 | BACE1 (0.46) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL1359776 | 0.76 | MAP4K4 (0.46) | PDE3BPDE3APDGFRBPDGFRAKMT2A | |
| SCHEMBL845999 | 0.76 | BACE1 (0.50) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL584342 | 0.76 | BACE1 (0.41) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL12686649 | 0.76 | CYP1A2 (0.57) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL4142083 | 0.76 | MET (0.38) | PDE3BPDE3ALMNAKMT2AALPL | |
| SCHEMBL21988901 | 0.76 | MAP4K4 (0.54) | BACE1PDE3BPDE3APDGFRBPDGFRA | |
| SCHEMBL16289408 | 0.76 | BACE1 (0.41) | BACE1PDE3BPDE3APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2022-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | CNR2 3473/4885BACE1 1210/4885PDE3B 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.