Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 11/20 | 0.38 |
| ▸ | BRAF | P15056 | 10/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885071 | 0.89 | XDH (0.39) | ROCK2ROCK1RAF1BRAFFLT3 | |
| SCHEMBL7884822 | 0.87 | FLT3 (0.35) | ROCK2ROCK1RAF1BRAFFLT3 | |
| SCHEMBL7873594 | 0.86 | XDH (0.40) | BRAFFLT3PDGFRBPDGFRAALOX15 | |
| SCHEMBL7873786 | 0.85 | RAF1 (0.37) | RAF1BRAFFLT3PDGFRBPDGFRA | |
| SCHEMBL7877940 | 0.85 | MAPK14 (0.39) | RAF1BRAFFLT3MAPK14PDGFRB | |
| SCHEMBL7884357 | 0.85 | KMT2A (0.37) | RAF1BRAFFLT3PDGFRBPDGFRA | |
| SCHEMBL7882069 | 0.84 | XDH (0.51) | FLT3PDGFRBPDGFRAALOX15XDH | |
| SCHEMBL7881139 | 0.84 | RAF1 (0.39) | RAF1BRAFFLT3MAPK14PDGFRB | |
| SCHEMBL7877886 | 0.83 | XDH (0.41) | BRAFFLT3PDGFRBPDGFRAALOX15 | |
| SCHEMBL7881783 | 0.83 | KMT2A (0.34) | ROCK2ROCK1RAF1BRAFFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |