Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.37 |
| ▸ | BRAF | P15056 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878083 | 0.86 | RAF1 (0.34) | RAF1BRAFKDRCHEK2PDGFRB | |
| SCHEMBL7881047 | 0.85 | LGALS8 (0.42) | ALDH1A1CHEK2PDGFRBPDGFRALGALS8 | |
| SCHEMBL7879701 | 0.85 | ROCK2 (0.41) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL7877951 | 0.85 | HRH4 (0.37) | ALDH1A1CHEK2PDGFRBPDGFRAFLT3 | |
| SCHEMBL7873405 | 0.85 | RAF1 (0.38) | RAF1BRAFKDRCHEK2PDGFRB | |
| SCHEMBL7885071 | 0.84 | XDH (0.39) | RAF1BRAFALDH1A1HPGDKDR | |
| SCHEMBL7881894 | 0.83 | CYP2C9 (0.44) | ALDH1A1PDGFRBPDGFRAFLT3LGALS8 | |
| SCHEMBL7879824 | 0.83 | APEX1 (0.35) | RAF1BRAFKDRXDH | |
| SCHEMBL7884833 | 0.83 | SIRT2 (0.41) | ALDH1A1CHEK2PDGFRBPDGFRAFLT3 | |
| SCHEMBL7884822 | 0.81 | FLT3 (0.35) | RAF1BRAFKDRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |