SCHEMBL7879735

SCHEMBL7879735

CC(C)(C)OC(=O)C1CCN(CO)CC1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.51
ALDH1A1 P00352 4/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TSHR P16473 1/20 0.43
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.39
RECQL P46063 1/20 0.39
GAA P10253 1/20 0.38
PKM P14618 1/20 0.38
HTT P42858 1/20 0.38
MAPT P10636 3/20 0.36
HSD17B10 Q99714 1/20 0.35
PTPN2 P17706 1/20 0.35
PTPN1 P18031 1/20 0.35
PTPN6 P29350 1/20 0.35
TP53 P04637 1/20 0.35
NR1H2 P55055 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7454861 0.86 HRH3 (0.49) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL7749087 0.86 SMN1; SMN2 (0.55) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL2799202 0.84 HRH3 (0.50) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL25698055 0.84 HRH3 (0.50) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL46308 0.83 HRH3 (0.49) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL19931764 0.83 HRH3 (0.49) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL1052899 0.81 HRH3 (0.48) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL31576115 0.81 HRH3 (0.48) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL8829186 0.81 HRH3 (0.48) HRH3ALDH1A1MEN1KMT2ATSHR
SCHEMBL9281583 0.81 SMN1; SMN2 (0.50) HRH3ALDH1A1MEN1KMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108558828-A The preparation method of tyrosine kinase inhibitor Vande Thani and its key intermediate 盐城师范学院 2018-09-21 CN disclosed
CN-104876852-B ZD6474 midbody compound and preparation method thereof 上海医药工业研究院 2017-09-26 CN disclosed
US-6248772-B1 HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2001-06-19 US disclosed
US-6169107-B1 USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS SUMITOMO PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-0708091-A2 Indoloylguanidine derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-04-24 EP disclosed